Extracellular type II phospholipase A2 (PLA2) In the inflammatory exudate of rat pleurisy.
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چکیده
منابع مشابه
Lipoprotein-associated phospholipase A2 (Lp-PLA2)
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متن کاملLipoprotein-associated phospholipase A2 (Lp-PLA2)
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متن کاملSequential release of TNFα and phospholipase A2 in a rat model of LPS-induced pleurisy
The levels of extracellular phospholipase A(2) (sPLA(2)) and TNFalpha, and cell accumulation were measured in the pleural washings obtained at different times following the induction of Escherichia coli lipopolysaccharide (LPS, 100 mug/cavity) pleurisy in rats. TNFalpha peaked at 2 hours (3036 +/- 160.3 units/ml) and decreased thereafter. Conversely, levels of sPLA(2) peaked at 48 hours (1.97 +...
متن کاملTherapeutic modulation of lipoprotein-associated phospholipase A2 (Lp-PLA2).
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a calcium-independent phospholipase A2 that circulates in plasma in association with lipoprotein particles, whereas in atherosclerotic plaques it is co-localized with macrophages. Lp-PLA2 generates two proinflammatory mediators, lysophosphatidylcholine and oxidized nonesterified fatty acids, which play a role in the development of atheroscler...
متن کاملIsolation and characterization of a phospholipase A2 from an inflammatory exudate.
Sterile peritoneal exudates produced in rabbits injected with 1% glycogen contain a phospholipase A activity in a cell-free supernatant fraction that hydrolyzed a synthetic phospholipid (1,2-diacyl-sn-glycero-3-phospho-ethanolamine) and phospholipids of autoclaved Escherichia coli. This phospholipase activity (phosphatidylacylhydrolase EC 3.1.1.4) exhibited an apparent bimodal pH optimum (pH 6....
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1016/s0618-8278(19)31747-5